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Myocardial Preservation - Translational Research and Clinical
Myocardial Preservation: Translational Research and Clinical Application
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Myocardial Preservation : Translational Research and Clinical
Long-term functional and structural preservation of precision
Heart regeneration and repair after myocardial infarction
Research Stanford Advanced Cardiovascular Therapeutics and
Myocardial ischaemia–reperfusion injury and cardioprotection
17 myocardial protection against ischemia-reperfusion injury is part of: basic cardiovascular physiology: from molecules to translational medical science.
Therefore, this translational study may provide addi- tional evidence on this effect of htk versus cel on myocardial protection in aged rat hearts.
Living myocardial slices overcome most of these limitations and therefore are considered the research model that can bridge the gap between in vitro and in vivo translational studies. Myocardial slices, a multicellular platform to study cardiac biology.
Myocardial protection is integral to the functioning of hearts in day to day cardiac surgery. However, due to the longer ischaemic times, it becomes pivotal in the management of organs during transplantation.
An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the working group on myocardial function of the european society of cardiology.
Basic and translational research conclusions the results of this first trial using ihht for myocardial protection against perioperative ischaemic myocardial.
Acellular hydrogels have shown promise in improving cardiac function after myocardial infarction in preclinical animal models. Contessotto et al developed a sheep model of non–st elevation myocardial infarction, a form of infarction that does not involve the full thickness of the wall of the heart. Treating this sheep model with a degradable elastin-like polypeptide hydrogel, which mimics.
This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications.
Myocardial protection, cardiac surgery, cardiac transplantation by prohibiting complementary messenger rnas (mrnas) translation into functional proteins.
This book presents a thorough review of myocardial preservation focusing on translational research and clinical applications, and provides a valuable reference.
Jun 18, 2018 at present, the most promising mechanical protection strategy of the heart seems to be remote ischemic conditioning, which increases myocardial.
Cardioprotective therapy use in clinical practice has occasionally led to negative studies.
Myocardial protection at a crossroads: the need for translation into clinical therapy.
Anesthetics and opioids provide myocardial protection against ischemia- reperfusion injury in a translational studies have shown promising results, ischemic.
Myocardial preservation: translational research and clinical application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.
Specifically, myocardial preconditioning is an intriguing adaptation by which brief ischemia and reperfusion prime the mitochondria so that a subsequent.
Cyclin a2 ( ccna2 ), normally silenced after birth in the mammalian heart, can induce cardiac repair in small-animal models of myocardial infarction. We report that delivery of the ccna2 gene to infarcted porcine hearts invokes a regenerative response. We used a catheter-based approach to occlude the left anterior descending artery in swine, which resulted in substantial myocardial infarction.
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The traditional philosophy of ex vivo organ preservation has been to limit metabolic activity by storing organs in hypothermic, static conditions. This methodology cannot provide longevity of hearts for more than 4–6 h and is thereby insufficient to expand the number of available organs. Albeit at lower rate, the breakdown of atp still occurs during hypothermia.
Current therapies for heart failure after myocardial infarction are limited and non-curative. Although regenerative approaches are receiving significant attention, clinical efforts that involve transplantation of presumed stem and progenitor cells have largely failed to deliver.
Nov 11, 2019 living myocardial slices, translational research essential during tissue development and for the maintenance of the adult cardiac phenotype.
Oct 19, 2020 conclusion: dnc provides equivalent myocardial protection, efficacy, and practice in global ischemia and future translational perspective.
Jul 31, 2020 keywords myocardial protection, cardioplegia, cardiac arrest, cold blood, open heart as well as in myocardial protection, cardioplegia is indicated for a practice in global ischaemia and future translational persp.
Here, we report preservation in vitro models incorporating the complexity and function of adult human tissues are highly desired for translational research. Whilst vital slices of human myocardium approach these demands, their rapid degeneration in tissue culture precludes long-term experimentation.
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Oct 6, 2020 pdf myocardial protection has become an essential adjunctive measure in cardiac surgery for a couple of decades, because since the 1950s,.
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